How Pills Are Absorbed in Your Body

Ever wondered what happens after you swallow a pill? How does it travel through your body and work its magic? Let’s take a closer look at this fascinating process.

Script: When you take a pill, the journey begins as it travels down your esophagus, reaching your stomach. In the stomach, the pill starts to dissolve in the acidic environment. This stomach acid breaks down the pill into smaller particles, making the active ingredients available for absorption. From here, the partially dissolved pill moves into the small intestine.

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Disclaimer:
“This video is for informational purposes only. It is not intended to replace professional medical advice, diagnosis, or treatment. Always consult with a doctor or qualified healthcare provider for personalized guidance and recommendations.”

Medical abortions, or abortion pills, now account for more than half of abortions in the U.S. Following the Supreme Court decision that overturned Roe v. Wade – the 1973 court case that established a woman’s the right to choose an abortion – attention has turned to abortion pills.

I explain how misoprostol and mifepristone work together to terminate a pregnancy, as well as the potential side effects of a medical abortion.

0:00 Pill-based abortions are more popular than ever
0:29 What are abortion pills?
1:23 How do abortion pills work?
2:19 How effective are medical abortions?
2:38 Are there any side effects or risks?
3:56 What happens to pill-based abortions now that Roe v Wade has been overturned?

I’m Daniela Hernandez, a health and science reporter for WSJ, and on this channel I’ll be covering a variety of subjects from neuroscience to the science of food and public health. If you’re interested in science and health and how cutting edge research impacts our lives, don’t forget to subscribe.

#Abortion #RoeVWade #DanielaHernandez
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MEDICAL ANIMATION TRANSCRIPT: Medication absorption is the movement of a drug from its site of administration into the blood. Oral drugs enter the stomach where they either dissolve and pass through the cell membranes of epithelial cells lining the stomach or travel undissolved through the stomach to the small intestine, which is the most common site of absorption. Here, drugs dissolve and pass through the intestinal wall. Oral drugs then travel through the portal venous system to the liver, where they undergo the first pass effect. During this process, the liver metabolizes some of the drug, either inactivating it or excreting it into bile for elimination from the body. The remaining amount of active drug leaves the liver and reaches general circulation and target organs. If a drug is administered via intravenous injection, it passes directly into the bloodstream, thus bypassing absorption in the GI tract. If administered through intramuscular or subcutaneous injection, the drug enters either muscle or subcutaneous tissue, where it passes through gaps between cells into capillary walls and then into general circulation or target organs, also bypassing absorption in the GI tract. Bioavailability is the net amount of a dose of a drug that is actually absorbed into the bloodstream. The bioavailability of oral drugs is less than 100% because of the first pass effect of the liver. In contrast, the bioavailability of IV drugs is 100% because they are not exposed to the first pass effect of the liver. Different drug formulations alter bioavailability, because they are not absorbed at the same rate or to the same extent. For example, tablets dissolve at varying rates. Enteric coated drugs dissolve in the small intestine, not the stomach. Because gastric emptying time differs between individuals, absorption times also vary. Sustained release formulas contain tiny spheres that dissolve at different rates, resulting in a steady drug release throughout the day, but also resulting in variable absorption. Some factors affecting drug absorption are the rate of dissolution. Drugs that dissolve faster are absorbed faster. Surface area, since the lining of the small intestine has more surface area than the lining of the stomach, most drugs are absorbed faster in the small intestine. Blood flow, the greater the concentration gradient between the drug-filled stomach and the rapidly flowing drug-free blood, the faster the absorption. Lipid solubility, highly lipid soluble drugs pass through the phospholipids in the cell membrane more easily than drugs of low lipid solubility. And PH partitioning, absorption is faster when the difference between the PH at the site of administration and the PH of the plasma attracts more drug molecules to ionize in the plasma. ♪ [music] ♪

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ANM11011
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E.R. physician Dr. Travis Stork explains that while most medications are taken by swallowing a pill or a capsule, some are taken sublingually, or under the tongue, depending on how the medication is meant to be absorbed by the body.
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This brief animation on the oral contraceptive pill will show you what you need to know about how the oral contraceptive pill works, how to use them, who they’re great for, and common side effects. Heard some myths or misconceptions? We’ll address those too. Visit our website www.mariestopes.org for more information on sexual and reproductive health, contraception, and where you can find our services.

Want to watch and learn more? Follow the links below for our animations on:
Condoms: https://youtu.be/hNcDm37yj5Q
Implants: https://youtu.be/9RJVTBFxKAM
Injection: https://youtu.be/_3YuMd7t9aM
IUD: https://youtu.be/SIcjaR69Yks
Tubal ligation: https://youtu.be/3SqeSSQhu3o
Vasectomy: https://youtu.be/4ESZgEPLtIg
Menstruation: https://youtu.be/2UqTUZ8pquo
Pregnancy: https://youtu.be/_Ibp86m6hjU
Male fertility: https://youtu.be/RO35Oj5sgmc

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